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Hepatitis C

by Icnaija

Hepatitis C is a viral infection of the liver. When a person has the hepatitis C virus (HCV) for several years, their liver can become inflamed. However, a person can live for years without even knowing that they have HCV. Once the symptoms start to show, the person usually already has liver damage, which can affect treatment and prognosis.

There are two main types of HCV: acute and chronic. Around 75–85% of acute cases become chronic. The immune system clears most other cases.

There are also different genotypes, or variations, of the virus. These strains of the virus have evolved over many years.

A person will usually discover that they have HCV either after a blood test or because symptoms of liver damage have started to appear. The symptoms of liver damage tend to appear when a person has had chronic HCV for many years.

Chronic HCV needs treatment to prevent liver damage and other complications. Liver damage and scarring can have an impact on a person’s overall prognosis and life expectancy.

Keep reading to learn more about the prognosis of different forms of HCV, as well as a person’s likely life expectancy.

Acute HCV
For some people whose immune systems can clear it, acute HCV is a short-lived viral infection. The sections below cover the possible symptoms and outlook of acute HCV.

Symptoms
A person with HCV may experience fever, fatigue, and loss of appetite.
Acute HCV usually produces no symptoms. If symptoms do occur in acute HCV, however, they may include:

  • Abdominal pain
  • Loss of appetite
  • Fever
  • Fatigue
  • dark urine
  • jaundice, or yellowing of the skin and eyes
    clay-colored bowel movements
  • nausea
  • vomiting
  • joint pain

People with acute HCV may not require any direct treatment. However, about 75–85% of people with an acute HCV infection may eventually develop a chronic HCV infection.

If a doctor is able to detect and diagnose acute HCV infection early, they will be able monitor it. Unless it develops into chronic HCV, there is very little risk of death from acute HCV.

With that said, acute HCV will develop into chronic HCV if the body does not spontaneously clear the virus within 6 months of infection.

Chronic HCV with no liver damage
For people with HCV who receive a diagnosis before any liver damage or scarring occurs, the prognosis will tend to be better than for people who receive a diagnosis after scarring or liver damage has already occurred.
The Centers for Disease Control and Prevention (CDC)Trusted Source suggest that people undergo testing for HCV, especially if they were born between 1945 and 1965, have used injectable drugs, or have other potential risk factors.

Detecting and diagnosing the infection early may allow the person to treat it before liver damage or scarring can occur.

Symptoms
The majority of people with chronic HCV will display no symptoms until decades after infection, unless other complications develop.

Some potential complications of chronic HCV include:

  • liver damage
  • cirrhosis, or permanent scarring of the liver
  • liver cancer
  • Liver failure

Treatment
Treatment will vary based on the genotype of the virus and the presence of any other health conditions a person has. Treatments are continually improving, making it possible for a person to live an active and normal life with HCV.

Following treatment, a person’s doctor will often check again for the viral load, or the amount of virus, in their blood. Treatment usually completely rids the body of the virus.
In other cases, a person may need to change their medications to better treat the virus.

In the United States, typical treatments for HCV used to include interferon, which is an injection, and ribavirin, which is an oral medication. However, newer medications called direct-acting antivirals (DAAs) are starting to make the treatment process shorter and more effective.

Certain DAAs can target specific genotypes of HCV. Targeted treatments can help improve the outcome for some people.

The prognosis of chronic HCV is typically very good, and as treatment continues to improve, it will only get better. Most people with chronic HCV can live a normal life, providing that doctors are able to diagnose it before any liver damage or other complications occur.

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